Kir4.1 Antibody: APC

Kir4.1, an inwardly rectifying potassium channel encoded by KCNJ10, plays a pivotal role in maintaining ion homeostasis and extracellular potassium buffering in the central nervous system (CNS) . Predominantly expressed in astrocytes, Kir4.1 is essential for regulating neuronal excitability, synaptic transmission, and neurovascular coupling. Disruption of Kir4.1 function has been increasingly implicated in the pathogenesis of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Huntington’s disease, and multiple sclerosis (MS) . Loss or dysfunction of Kir4.1 impairs astrocytic potassium clearance and glutamate uptake, leading to excitotoxicity, oxidative stress, and chronic neuroinflammation—key drivers of progressive neuronal damage. Moreover, Kir4.1 dysregulation has been associated with blood-brain barrier breakdown and altered astrocyte-neuron metabolic coupling, further exacerbating neurodegenerative cascades. Recent studies highlight Kir4.1 as a potential biomarker and therapeutic target in neurodegeneration. Modulating Kir4.1 activity may restore glial function, reduce excitotoxic burden, and enhance neuroprotection. Its involvement in both genetic and acquired neurological disorders underscores its translational relevance across diverse disease models. As neuroscience advances toward glia-centered therapeutic strategies, Kir4.1 stands at the intersection of ion channel physiology, neuroinflammation, and neurodegeneration—offering a promising avenue for intervention and biomarker development.

Kir4.1, KCNJ10, Kcnj10, IRK1, IRK10_HUMAN, KIR1.2, Inward rectifier K (+) channel Kir1.2, Inward rectifier potassium channel Kir1.2, ATP-dependent inwardly rectifying potassium channel Kir4.1, Glial ATP dependent inwardly rectifying potassium channel KIR4.1, Potassium inwardly rectifying channel subfamily J member 10, Potassium channel inwardly rectifying subfamily J member 10, Potassium channel KCNJ 10, Potassium channel subfamily J member 10, ATP sensitive inward rectifier potassium channel 10, ATP-sensitive inward rectifier potassium channel 10, BIRK10, SESAME

A 1:1000 dilution of SPC-700 was sufficient for detection of Kir4.1 in 15 µg of rat liver cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.