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p53 Antibody: RPE

Rabbit Anti-Human p53 Polyclona

Product Specifications

Background

The p53 protein (tumor protein 53 or TP53) is a DNA-binding cell cycle-regulating transcription factor that governs cell division and the fine balance between cell death and cell survival (1). P53 plays a critical role in tumor suppression and hence it is often described as "the guardian of the genome", "the guardian angel gene", or the "master watchman." This also refers to its role in conserving stability by preventing genome mutation (2). Defects in p53 are linked to >50% of human cancers, and restoring p53 function to these cancer cells can induce growth arrest and apoptosis (3). When p53 has been damaged, it can also lead to autoimmune disorders (4, 5).

Specifications

Predicted molecular weight at ~43.7kDa. Observed bands at ~53kDa.

Product Name Alternative

Cancer, Cell Cycle, p53 Pathway, Cancer, Tumor suppressors, Apoptosis, Cell Signaling, Epigenetics and Nuclear Signaling, DNA/RNA, DNA Damage and Repair

UNSPSC

12352203

Gene ID

7157

Swiss Prot

P04637

Accession Number

NP_000537.3

Cellular Locus

Cytoplasm | Nucleus | PML body | Endoplasmic Reticulum | Mitochondrion matrix

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide from the C-terminal of human tumor protein p53.

Target

p53

Clonality

Polyclonal

Conjugation

RPE

Validated Applications

WB,IHC,ICC/IF

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Georescu C.V., Saftoiu A., Georgescu C.C., Ciurea R. and Ciurea T. (2007) J Gastrointestin Liver Dis. 16(2): 133-9. 2. Strachan T., et al. (1999) Human Molecular Genetics 2. Ch. 18: Cancer Genetics. 3. Hansen J.E., et al. (2007) Cancer Research 67: 1769-1774. 4. Di Cesare E., et al. (2001) Ann Clin Lab Sci 31: 253-8. 5. Akere A., Otegbayo J.A. (2007) Singapore Med J. 48(1): 41-4.

Product Datasheet

https://cdn.gentaur.com/products/400/4415681/datasheet/spc-682d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4415681/msds/spc-682d-rpe.pdf

CAS Number

9007-83-4

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