VMP1 Antibody: RPE

Vacuole Membrane Protein 1 (VMP1) is an endoplasmic reticulum (ER) -localized, multi-spanning membrane protein essential for the initiation of autophagy and the maintenance of ER-organelle communication. VMP1 plays a pivotal role in forming autophagosomes and regulating membrane contact sites between the ER and other organelles, including mitochondria, endosomes, and lipid droplets. In the nervous system, VMP1 is crucial for neuronal homeostasis. It facilitates the clearance of damaged proteins and organelles through the autophagy-lysosome pathway—a process vital for long-lived neurons. Loss of VMP1 function disrupts autophagic flux, leading to the accumulation of protein aggregates, damaged mitochondria, and swollen ER structures. These cellular stressors are strongly associated with the pathogenesis of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis. Recent studies have shown that VMP1 deficiency in dopaminergic neurons results in progressive motor deficits, axonal degeneration, and α-synuclein accumulation—hallmarks of Parkinsonian neurodegeneration. Mechanistically, VMP1 is required for LC3 recruitment and Beclin-1 interaction, both essential steps in autophagosome formation. As a master regulator of autophagy and ER-organelle dynamics, VMP1 represents a promising therapeutic target for neurodegenerative disease intervention. Its role in maintaining neuronal integrity positions it at the forefront of research into brain aging and neuroprotection.

VMP1, Vacuole Membrane Protein 1, TMEM49, Transmembrane Protein 49, TANGO5, Transport And Golgi Organization 5 Homolog, EPG3, Ectopic P-Granules Autophagy Protein 3 Homolog, TDC1, HSPC292

Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane | Multi-Pass Membrane Protein | Cell Membrane | Multi-Pass Membrane Protein | Vacuole Membrane | Multi-Pass Membrane Protein | Endoplasmic Reticulum

A 1:1000 dilution of SPC-680 was sufficient for detection of VMP1 in 15 µg of Human 293T Cell Lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane | Multi-Pass Membrane Protein | Cell Membrane | Multi-Pass Membrane Protein | Vacuole Membrane | Multi-Pass Membrane Protein | Endoplasmic Reticulum