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ATG2A Antibody: PerCP

Rabbit Anti-Human ATG2A Polyclonal

Product Specifications

Background

Autophagy-related protein 2A (ATG2A) is a core component of the autophagy machinery and a member of the ATG2 protein family, essential for maintaining cellular homeostasis under stress conditions. ATG2A plays a pivotal role in autophagosome biogenesis by facilitating membrane expansion and lipid transfer at the phagophore assembly site. In parallel, ATG2A regulates lipid droplet morphology and dispersion, linking autophagy to lipid metabolism—two processes increasingly recognized as central to neuronal health and disease. In the context of neurodegenerative disorders, ATG2A is emerging as a key player in the cellular response to proteotoxic stress. Impaired autophagy and disrupted lipid homeostasis are hallmark features of diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, where accumulation of misfolded proteins and dysfunctional organelles contributes to neuronal death. By coordinating membrane dynamics and lipid trafficking, ATG2A supports the clearance of toxic aggregates and sustains energy balance in neurons. Recent studies suggest that dysregulation of ATG2A function may exacerbate neurodegenerative pathology by impairing autophagic flux and altering lipid signaling pathways. As such, ATG2A represents a promising target for therapeutic strategies aimed at restoring autophagy and metabolic balance in the aging and diseased brain.

CAS Number

9007-83-4

Specifications

Predicted molecular weights at ~213kDa. Other observed bands around ~90-100kDa to be expected.

Product Name Alternative

ATG2A, KIAA0404, ATG2 autophagy related homolog A, ATG2a_HUMAN, BC023754, 1810013C15Rik

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

23130

Swiss Prot

Q2TAZ0

Accession Number

NP_055919.2

Cellular Locus

Preautophagosomal Structure Membrane | Peripheral membrane protein

Host

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide from the C-terminal of human ATG2A

Target

ATG2A

Clonality

Polyclonal

Conjugation

PerCP

Type

Polyclonal

Applications

WB | ICC/IF

Validated Applications

WB,IHC,ICC/IF,ELISA

Field of Research

Neuroscience | Cancer | Autophagy | Cardiovascular System | Heart

Purification

Peptide Affinity Purified

Detection Range

A 1:1000 dilution of SPC-652 was sufficient for detection of ATG2A on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000) ; ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N. (2012) Mol Biol Cell. 23 (5) : 896-909.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/2015/05/PerCP-Fluorescent-conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Predicted molecular weights at ~213kDa. Other observed bands around ~90-100kDa to be expected.

Species

Human | Mouse

Location

Preautophagosomal Structure Membrane | Peripheral membrane protein

Immunogen Species

Human

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