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ULK1 Antibody: RPE

Rabbit Anti-Human ULK1 Polyclonal

Product Specifications

Background

UNC-51 like kinase 1 (ULK1) is widely expresed and contains an amino-terminal kinase domain followed by a central proline-serine rich domain and a highly conserved carboxy-terminal domain. It has been linked to axon growth and is essential for autophagy. Structurally, ULK1 is similar to ATG1, and it appears that both Atg1/ULK1 can bind to several ATG proteins regulating phosphorylation states and protein trafficking.

Specifications

Detects ~100 kDa.

Product Name Alternative

Neuroscience, Cell Signaling, Cardiovascular System, Heart, Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, Cell Signaling, Metabolism, Mitochondrial Metabolism

UNSPSC

12352203

Gene ID

8408

Swiss Prot

O75385

Accession Number

NP_003556.1

Cellular Locus

Cytoplasm | Cytosol | Preautophagosomal Structure

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide from the mid-protein of Human ULK1 (aa. 567-577)

Target

ULK1

Clonality

Polyclonal

Conjugation

RPE

Tissue Specificity

Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.

Validated Applications

WB,IHC,ICC/IF

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Okazaki N., et al. (2000) Brain Res Mol Brain Res. 85: 1-12. 2. Young A.R., et al. (2006) J Cell Sci. 119: 3888-900. 3. Kamada Y., et al. (2000) J Cell Biol. 150: 1507-13. 4. Lee S.B, et al. (2007) EMBO Rep. 8: 360-5. 5. Hara T., et al. (2008) J Cell Biol. 181: 497-510.

Product Datasheet

https://cdn.gentaur.com/products/400/4415156/datasheet/spc-640d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4415156/msds/spc-640d-rpe.pdf

CAS Number

9007-83-4

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