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ULK1 Antibody: ATTO 594

Rabbit Anti-Human ULK1 Polyclonal

Product Specifications

Background

UNC-51 like kinase 1 (ULK1) is widely expresed and contains an amino-terminal kinase domain followed by a central proline-serine rich domain and a highly conserved carboxy-terminal domain. It has been linked to axon growth and is essential for autophagy. Structurally, ULK1 is similar to ATG1, and it appears that both Atg1/ULK1 can bind to several ATG proteins regulating phosphorylation states and protein trafficking.

Specifications

Detects ~100 kDa.

Product Name Alternative

Neuroscience, Cell Signaling, Cardiovascular System, Heart, Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, Cell Signaling, Metabolism, Mitochondrial Metabolism

UNSPSC

12352203

Gene ID

8408

Swiss Prot

O75385

Accession Number

NP_003556.1

Cellular Locus

Cytoplasm | Cytosol | Preautophagosomal Structure

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide from the mid-protein of Human ULK1 (aa. 567-577)

Target

ULK1

Clonality

Polyclonal

Conjugation

ATTO 594

Tissue Specificity

Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.

Validated Applications

IHC,ICC/IF

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Okazaki N., et al. (2000) Brain Res Mol Brain Res. 85: 1-12. 2. Young A.R., et al. (2006) J Cell Sci. 119: 3888-900. 3. Kamada Y., et al. (2000) J Cell Biol. 150: 1507-13. 4. Lee S.B, et al. (2007) EMBO Rep. 8: 360-5. 5. Hara T., et al. (2008) J Cell Biol. 181: 497-510.

Product Datasheet

https://cdn.gentaur.com/products/400/4415138/datasheet/spc-640d-a594.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4415138/msds/spc-640d-a594.pdf

CAS Number

9007-83-4

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