ATG4B Antibody: RPE
Rabbit Anti-Human ATG4B Polyclonal
Product Specifications
Background
Autophagy related 4B, cysteine peptidase (ATG4B or APG4B) is a C-54 cysteine protease that also belongs to the family of autophagin poteins. Specifically it cleaves LC3, and mutations can be associated with strong inhibition of autophagosome formation.
CAS Number
9007-83-4
Specifications
Detects ~44 kDa.
Product Name Alternative
Cancer, Autophagy, Cardiovascular System, Heart, Cell Signaling
UNSPSC
12352203
Gene ID
23192
Swiss Prot
Q9Y4P1
Accession Number
NP_037457.3
Cellular Locus
Cytoplasm
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide from the N-terminal to mid of Human ATG4B (aa. 94-106)
Target
ATG4B
Clonality
Polyclonal
Conjugation
RPE
Tissue Specificity
Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.
Validated Applications
WB,IHC,ICC/IF
Purification
Peptide Affinity Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kabeya Y., et al. (2004) J Cell Sci. 117: 2805-2812.
2. Tanida I., et al. (2004) J Biol Chem. 279: 36268-36276.
3. Hemelaar J., et al. (2003) J Biol Chem. 278: 51841-51850.
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