ATG4B Antibody: RPE

Rabbit Anti-Human ATG4B Polyclonal

Product Specifications

Background

Autophagy related 4B, cysteine peptidase (ATG4B or APG4B) is a C-54 cysteine protease that also belongs to the family of autophagin poteins. Specifically it cleaves LC3, and mutations can be associated with strong inhibition of autophagosome formation.

CAS Number

9007-83-4

Specifications

Detects ~44 kDa.

Product Name Alternative

Cancer, Autophagy, Cardiovascular System, Heart, Cell Signaling

UNSPSC

12352203

Gene ID

23192

Swiss Prot

Q9Y4P1

Accession Number

NP_037457.3

Cellular Locus

Cytoplasm

Host

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide from the N-terminal to mid of Human ATG4B (aa. 94-106)

Target

ATG4B

Clonality

Polyclonal

Conjugation

RPE

Tissue Specificity

Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.

Validated Applications

WB,IHC,ICC/IF

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Kabeya Y., et al. (2004) J Cell Sci. 117: 2805-2812. 2. Tanida I., et al. (2004) J Biol Chem. 279: 36268-36276. 3. Hemelaar J., et al. (2003) J Biol Chem. 278: 51841-51850.