ATG4B Antibody: ATTO 488
Rabbit Anti-Human ATG4B Polyclonal
Product Specifications
Background
Autophagy related 4B, cysteine peptidase (ATG4B or APG4B) is a C-54 cysteine protease that also belongs to the family of autophagin poteins. Specifically it cleaves LC3, and mutations can be associated with strong inhibition of autophagosome formation.
CAS Number
9007-83-4
Specifications
Detects ~44 kDa.
Product Name Alternative
Cancer, Autophagy, Cardiovascular System, Heart, Cell Signaling
UNSPSC
12352203
Gene ID
23192
Swiss Prot
Q9Y4P1
Accession Number
NP_037457.3
Cellular Locus
Cytoplasm
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide from the N-terminal to mid of Human ATG4B (aa. 94-106)
Target
ATG4B
Clonality
Polyclonal
Conjugation
ATTO 488
Tissue Specificity
Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.
Validated Applications
IHC,ICC/IF
Purification
Peptide Affinity Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kabeya Y., et al. (2004) J Cell Sci. 117: 2805-2812.
2. Tanida I., et al. (2004) J Biol Chem. 279: 36268-36276.
3. Hemelaar J., et al. (2003) J Biol Chem. 278: 51841-51850.
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