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UVRAG Antibody: Biotin

Rabbit Anti-Human UVRAG Polyclonal

Product Specifications

Background

UVRAG (Ultraviolet irradiation resistance-associated gene) encodes a multifunctional protein that plays a pivotal role in cellular homeostasis, particularly through its regulation of autophagy and endosomal trafficking. As a key activator of the Beclin1–PI3KC3 complex, UVRAG promotes autophagosome formation and maturation, facilitating the clearance of damaged organelles and misfolded proteins—processes that are often disrupted in neurodegenerative diseases. In addition to its autophagic functions, UVRAG contributes to genomic stability by participating in DNA repair and maintaining centrosome integrity. These roles are especially critical in neurons, which are highly sensitive to oxidative stress, DNA damage, and impaired proteostasis. Dysregulation of UVRAG has been linked to pathological features common in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Impaired UVRAG function can lead to defective autophagy, accumulation of toxic protein aggregates, and increased neuronal vulnerability. Given its dual role in autophagy and genome maintenance, UVRAG is emerging as a promising target in neuroscience research. Modulating its activity may offer therapeutic potential for restoring cellular balance, enhancing neuronal survival, and slowing the progression of neurodegenerative diseases.

CAS Number

9007-83-4

Specifications

Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.

Product Name Alternative

UVRAG, UV radiation resistance-associated, UVRAG_HUMAN, DHTX

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

7405

Swiss Prot

Q9P2Y5

Accession Number

NP_003360.2

Cellular Locus

Endosome | Lysosome | Endoplasmic reticulum | Nucleus | Chromosome | Centromere

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide from the mid-protein of human UVRAG

Target

UVRAG

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal

Applications

WB | ICC/IF

Validated Applications

WB,IHC,ICC/IF |ELISA

Field of Research

Cancer | Apoptosis | Autophagy | Cell Signaling | Epigenetics and Nuclear Signaling | Cardiovascular System | Heart

Purification

Peptide Affinity Purified

Detection Range

A 1:1000 dilution of SPC-606 was sufficient for detection of UVRAG on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000) ; ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

136.36mM Ethanolamine, 133.23 mM Chlorides, 9.55mM Phosphates, 9.55mM Sodium Bicarbonate.

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87. 2. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87. 3. Ionov, Y. et al. (2004) Oncogene. 23: 639-45. 4. Kim, M.S. et al. (2008) Hum Pathol. 39: 1059-63.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/Biotin-Protein-Conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.

Species

Human | Mouse | Rat

Location

Endosome | Lysosome | Endoplasmic reticulum | Nucleus | Chromosome | Centromere

Immunogen Species

Human

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