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UVRAG Antibody: ATTO 488

Rabbit Anti-Human UVRAG Polyclonal

Product Specifications

Background

UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (1). Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (2). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (3-4). It is highly expressed in the brain, lung, kidney and liver.

Specifications

Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.

Product Name Alternative

Cancer, Apoptosis, Autophagy, Cell Signaling, Epigenetics and Nuclear Signaling, Cardiovascular System, Heart

UNSPSC

12352203

Gene ID

7405

Swiss Prot

Q9P2Y5

Accession Number

NP_003360.2

Cellular Locus

Endosome | Lysosome | Endoplasmic reticulum | Nucleus | Chromosome | Centromere

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide from the mid-protein of human UVRAG

Target

UVRAG

Clonality

Polyclonal

Conjugation

ATTO 488

Validated Applications

IHC,ICC/IF

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87. 2. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87. 3. Ionov, Y. et al. (2004) Oncogene. 23: 639-45. 4. Kim, M.S. et al. (2008) Hum Pathol. 39: 1059-63.

Product Datasheet

https://cdn.gentaur.com/products/400/4414511/datasheet/spc-606d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4414511/msds/spc-606d-a488.pdf

CAS Number

9007-83-4

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