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Beclin 1 Antibody

Rabbit Anti-Human Beclin 1 Polyclonal

Product Specifications

Background

Beclin 1 is the mammalian ortholog of the yeast autophagy -related gene Atg6. It regulates autophagy and has an inportant role in development, tumorigenesis and neurodegeneration (1). Beclin 1 is localized within cytoplasmic structures including the mitochondria, yet overexpression reveals some nuclear staining (2). Researchers have found that schizonphrenia is associated with low levels of Beclin-1 in the hippocampus (3). It may also protect against infection by a neuorvirulent train of Sindbis virus (4).

Specifications

Predicted molecular weight at ~51kDa.

Product Name Alternative

Cell Signaling, Epigenetics and Nuclear Signaling, Transcription, Cancer, Tumor suppressors, Cancer, Autophagy, Cancer, Cancer Metabolism

UNSPSC

12352203

Gene ID

8678

Swiss Prot

Q14457

Accession Number

NP_001300927.1

Cellular Locus

Cytoplasm | Golgi apparatus | Trans-Golgi network membrane| Endosome | Endoplasmic reticulum membrane | Mitochondrion | Mitochondrion membrane | Cytoplasmic vesicle | Autophagosome

Host

Rabbit

Species Reactivity

Human,Rat

Immunogen

Synthetic peptide from the C-terminus of human Beclin 1

Target

Beclin 1

Clonality

Polyclonal

Conjugation

Unconjugated

Validated Applications

WB,ICC/IF

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zhong Y., et al. (2009) Nat Cell Biol. 11(4): 468-476. 2. Liang X.H., et al. (2001) Cancer Res. 61: 3443-3449. 3. Merenlender-Wagner A., et al. (2013) Mol. Psychiatry 20:126-132. 4. Liang X.H., et al. (1998) J Virol. 72: 8586-8596.

Product MSDS

https://cdn.gentaur.com/products/400/4414408/msds/spc-601s.pdf

CAS Number

9007-83-4

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