Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Beclin 1 Antibody: Biotin

Rabbit Anti-Human Beclin 1 Polyclonal

Product Specifications

Background

Beclin 1 is the mammalian ortholog of the yeast autophagy -related gene Atg6. It regulates autophagy and has an important role in development, tumorigenesis and neurodegeneration (1). Beclin 1 is localized within cytoplasmic structures including the mitochondria, yet overexpression reveals some nuclear staining (2). Researchers have found that schizonphrenia is associated with low levels of Beclin-1 in the hippocampus (3). It may also protect against infection by a neuorvirulent strain of Sindbis virus (4).

Specifications

Predicted molecular weight at ~51kDa. Observed a secondary band on some lysates at ~30kDa.

Product Name Alternative

Cell Signaling, Epigenetics and Nuclear Signaling, Transcription, Cancer, Tumor suppressors, Cancer, Autophagy, Cancer, Cancer Metabolism

UNSPSC

12352203

Gene ID

8678

Swiss Prot

Q14457

Accession Number

NP_001300927.1

Cellular Locus

Cytoplasm | Golgi apparatus | Trans-Golgi network membrane| Endosome | Endoplasmic reticulum membrane | Mitochondrion | Mitochondrion membrane | Cytoplasmic vesicle | Autophagosome

Host

Rabbit

Species Reactivity

Human,Rat

Immunogen

Synthetic peptide from the mid-protein of human Beclin 1

Target

Beclin 1

Clonality

Polyclonal

Conjugation

Biotin

Validated Applications

WB,IHC,ICC/IF |ELISA

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

136.36mM Ethanolamine, and 9.55mM Sodium Bicarbonate in 95.45% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zhong Y., et al. (2009) Nat Cell Biol. 11(4): 468-476. 2. Liang X.H., et al. (2001) Cancer Res. 61: 3443-3449. 3. Merenlender-Wagner A., et al. (2013) Mol. Psychiatry 20:126-132. 4. Liang X.H., et al. (1998) J Virol. 72: 8586-8596.

Product Datasheet

https://cdn.gentaur.com/products/400/4414371/datasheet/spc-600d-bi.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4414371/msds/spc-600d-bi.pdf

CAS Number

9007-83-4

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

ANGPT1, CT (ANGPT1, KIAA0003, Angiopoietin-1) (MaxLight 750)
MBS6273464-01 0.1 mL

ANGPT1, CT (ANGPT1, KIAA0003, Angiopoietin-1) (MaxLight 750)

Ask
View Details
ANGPT1, CT (ANGPT1, KIAA0003, Angiopoietin-1) (MaxLight 750)
MBS6273464-02 5x 0.1 mL

ANGPT1, CT (ANGPT1, KIAA0003, Angiopoietin-1) (MaxLight 750)

Ask
View Details
Canine Metallotinein-1 ELISA kit
E08M1104-01 48 Well

Canine Metallotinein-1 ELISA kit

Ask
View Details
Canine Metallotinein-1 ELISA kit
E08M1104-02 96 Well

Canine Metallotinein-1 ELISA kit

Ask
View Details
cathepsin 1 shRNA Plasmid (m)
sc-77417-SH 20 µg

cathepsin 1 shRNA Plasmid (m)

Ask
View Details
Anti-Zebrafish wnt3a Polyclonal Antibody
ZA461014-01 50 µg

Anti-Zebrafish wnt3a Polyclonal Antibody

Ask
View Details