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Beclin 1 Antibody: APC

Rabbit Anti-Human Beclin 1 Polyclonal

Product Specifications

Background

Beclin 1 is the mammalian ortholog of the yeast autophagy -related gene Atg6. It regulates autophagy and has an important role in development, tumorigenesis and neurodegeneration (1). Beclin 1 is localized within cytoplasmic structures including the mitochondria, yet overexpression reveals some nuclear staining (2). Researchers have found that schizonphrenia is associated with low levels of Beclin-1 in the hippocampus (3). It may also protect against infection by a neuorvirulent strain of Sindbis virus (4).

Specifications

Predicted molecular weight at ~51kDa. Observed a secondary band on some lysates at ~30kDa.

Product Name Alternative

Cell Signaling, Epigenetics and Nuclear Signaling, Transcription, Cancer, Tumor suppressors, Cancer, Autophagy, Cancer, Cancer Metabolism

UNSPSC

12352203

Gene ID

8678

Swiss Prot

Q14457

Accession Number

NP_001300927.1

Cellular Locus

Cytoplasm | Golgi apparatus | Trans-Golgi network membrane| Endosome | Endoplasmic reticulum membrane | Mitochondrion | Mitochondrion membrane | Cytoplasmic vesicle | Autophagosome

Host

Rabbit

Species Reactivity

Human,Rat

Immunogen

Synthetic peptide from the mid-protein of human Beclin 1

Target

Beclin 1

Clonality

Polyclonal

Conjugation

APC

Validated Applications

IHC,ICC/IF

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zhong Y., et al. (2009) Nat Cell Biol. 11(4): 468-476. 2. Liang X.H., et al. (2001) Cancer Res. 61: 3443-3449. 3. Merenlender-Wagner A., et al. (2013) Mol. Psychiatry 20:126-132. 4. Liang X.H., et al. (1998) J Virol. 72: 8586-8596.

Product Datasheet

https://cdn.gentaur.com/products/400/4414369/datasheet/spc-600d-apc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4414369/msds/spc-600d-apc.pdf

CAS Number

9007-83-4

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