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Amyloid Fibrils (OC) Antibody: HRP

Rabbit Anti-Human Amyloid Fibrils (OC) Polyclonal

Product Specifications

Background

Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).

Specifications

Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrillar oligomers or natively folded proteins. Expected to detect in Mouse and Rat based on species homology.

Product Name Alternative

Neuroscience, Cell Signaling, Cardiovascular System, Blood, Neurodegeneration, Alzheimer's Disease, Amyloid

UNSPSC

12352203

Cellular Locus

Membrane

Host

Rabbit

Species Reactivity

Human

Immunogen

Fibrils prepared from human amyloid beta 42 peptide

Target

Amyloid Fibrils (OC)

Clonality

Polyclonal

Conjugation

HRP

Validated Applications

WB,IHC,ELISA

Purification

Protein A Purified

Dilution

WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.

Product Datasheet

https://cdn.gentaur.com/products/400/4414353/datasheet/spc-507d-hrp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4414353/msds/spc-507d-hrp.pdf

CAS Number

9007-83-4

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