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Amyloid Oligomers (A11) Antibody: FITC

Rabbit Anti-Human Amyloid Oligomers (A11) Polyclonal

Product Specifications

Background

Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).

Specifications

Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Product Name Alternative

Neuroscience, Cell Signaling, Cardiovascular System, Blood, Neurodegeneration, Alzheimer's Disease, Amyloid

UNSPSC

12352203

Gene ID

8666

Swiss Prot

P05067

Accession Number

NM_000484.2

Cellular Locus

Membrane

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Eukaryote

Immunogen

Synthetic molecular mimic of soluble human amyloid beta oligomers

Target

Amyloid Oligomers (A11)

Clonality

Polyclonal

Conjugation

FITC

Validated Applications

IHC,ICC/IF

Purification

Protein A Purified

Dilution

The suggested dilution for the current lot of SPC-506 in Western Blot and Dot Blot is 1:100; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547. 2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366. 3. Kayed R., et al. (2003) Science. 300(5618): 486-489.

Product Datasheet

https://cdn.gentaur.com/products/400/4414327/datasheet/spc-506d-fitc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4414327/msds/spc-506d-fitc.pdf

CAS Number

9007-83-4

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