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Aquaporin 4 Antibody

Rabbit Anti-Rat Aquaporin 4 Polyclonal

Product Specifications

Background

Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 4 is constitutively expressed in the basolateral cell membrane of principal collecting duct cells in the kidney and provide a pathway for water to exit these cells (3). It is also expressed in astrocytes and is up regulated by direct insult to the CNS (4). Aquaporin 4 has been proposed as the primary autoimmune target in neuromyelitis optica ( 5, 6).

Specifications

Detects ~35kDa. May detect larger glycosylated bands ~50kDa.

Product Name Alternative

Neuroscience, Neurotransmission, Ion Channels, Aquaporins

UNSPSC

12352203

Gene ID

25293

Swiss Prot

P47863

Accession Number

NP_036957.1

Cellular Locus

Membrane

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Produced against the C-terminal peptide (Sequence N-CTKGSYMEVEDNRSQVETED) of rat aquaporin 4

Target

Aquaporin 4

Clonality

Polyclonal

Conjugation

Unconjugated

Validated Applications

WB,IHC,ICC/IF

Purification

Protein A Purified

Concentration

1 mg/ml

Dilution

WB (1:2000), IHC (1:200), ICC/IF (1:400); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Gonen T., Walz T. (2006) Q. Rev. Biophys. 39(4): 361-396. 2. Knepper M.A. (1994) Proc Natl. Acad Sci. USA. 91(14): 6255-6258. 3. Agre P., Nielsen S. (1996) Nephrologie. 17(7): 409-415. 4. Nagelhus E.A., Mathiisen T.M., Ottersen O.P. (2004) Neuroscience. 129(4): 905-913. 5. Lennon V.A., Kryzer T.J., Pittock S.J., Verkman A.S., Hinson S.R. (2005) J Exp Med. 202(4): 473-477. 6. Bradl M., Lassmann D.H. (2008) Int. MS Journal/MS Forum. 15(3): 75-78.

Product MSDS

https://cdn.gentaur.com/products/400/4414284/msds/spc-505d.pdf

CAS Number

9007-83-4

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