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Aquaporin 2 Antibody: ATTO 488

Rabbit Anti-Rat Aquaporin 2 Polyclonal

Product Specifications

Background

Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 2 is the vasopressin-regulated water channel of the apical membrane of collecting duct cells. It is located in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes. When it is needed vasopressin binds to the cell surface vasopressin receptor, activating a signaling pathway that cause AQP2 containing vesicles to fuse with the plasma membrane so the AQP2 can be used by the cell (3). Defects in AQP2 area cause of an autosomal dominant form of nephrogenic diabetes insipidus (NDI) (4).

Specifications

Detects ~28.8kDa. May detect larger glycosylated bands ~35-50kDa.

Product Name Alternative

Neuroscience, Neurotransmission, Ion Channels, Aquaporins

UNSPSC

12352203

Gene ID

25386

Swiss Prot

P34080

Accession Number

NP_037041.2

Cellular Locus

Cell Membrane | Apical Cell Membrane | Basolateral Cell Membrane | Cytoplasmic Vesicle | Cytoplasmic Vesicle Membrane | Golgi Apparatus

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Produced against the C-terminal peptide (Sequence N-CLKGLEPDTDWEEREVRRRQ) of rat aquaporin 2

Target

Aquaporin 2

Clonality

Polyclonal

Conjugation

ATTO 488

Validated Applications

IHC,ICC/IF

Purification

Protein A Purified

Concentration

1 mg/ml

Dilution

WB (1:2000), IHC (1:200), ICC/IF (1:400); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Gonen T., Walz T. (2006) Q. Rev. Biophys. 39(4): 361-396. 2. Knepper M.A. (1994) Proc Natl. Acad Sci. USA. 91(14): 6255-6258. 3. Lodish H.F. (2008) Molecular Cell Biology. New York: W.H. Freeman. Print. 445. 4. www.vivo.colostate.edu/hbooks/molecules/aquaporins.html

Product Datasheet

https://cdn.gentaur.com/products/400/4414236/datasheet/spc-503d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4414236/msds/spc-503d-a488.pdf

CAS Number

9007-83-4

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