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UT-A1 Antibody: ATTO 488

Rabbit Anti-Rat UT-A1 Polyclonal

Product Specifications

Background

UT-A1, a kidney-specific urea transporter is expressed in the renal collecting duct where it mediates trans-epithelial urea transport and is a target for regulation by vasopressin. Urea movement out of the collecting duct in the inner medulla of the kidney allows accumulation of urea in the medullary interstitium, thereby allowing maximum water reabsorption from the collecting ducts. (The antibody also recognizes a second protein from the UT-A gene driven by transcription from an alternative promoter and expressed in the thin descending limb of Henle, viz. UT-A2) (1, 2).

Specifications

Detects ~97 and 127kDa.

Product Name Alternative

Neuroscience, Pumps/Transporters, Urea Transporters

UNSPSC

12352203

Gene ID

54302

Swiss Prot

Q62668

Accession Number

NP_062220

Cellular Locus

Cell Membrane | Apical Cell Membrane

Host

Rabbit

Species Reactivity

Rat,Mouse

Immunogen

Produced against a synthetic peptide mapped to the C-terminal tail (amino acids 911-929) of rat UT-A1 (antibody designation L194)

Target

UT-A1

Clonality

Polyclonal

Conjugation

ATTO 488

Tissue Specificity

Isoform 1 and isoform 2 are expressed in the inner medulla of the kidney. Isoform 3 and isoform 4 are expressed in both the inner and outer renal medulla.

Validated Applications

IHC,ICC/IF

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000); IHC (1:25); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Nielsen S., et al. (1996) Proc Natl Acad Sci U S A. 93(11): 5495-500. 2. Smith C.P. (2009) Exp Physiol. 94(2): 180-185.

Product Datasheet

https://cdn.gentaur.com/products/400/4414186/datasheet/spc-406d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4414186/msds/spc-406d-a488.pdf

CAS Number

9007-83-4

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