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NCC Antibody: HRP

Rabbit Anti-Rat NCC Polyclonal

Product Specifications

Background

NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis (1). Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC (2). Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension (1). Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat (3).

Specifications

Detects ~160kDa.

Product Name Alternative

Cancer, Neuroscience, Pumps/Transporters, Ion Pumps/Transporters

UNSPSC

12352203

Gene ID

54300, 6559

Swiss Prot

P55018, P55017

Accession Number

NP_062218, NP_000330

Cellular Locus

Membrane

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Dog

Immunogen

Produced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal

Target

NCC

Clonality

Polyclonal

Conjugation

HRP

Validated Applications

WB,IHC,ELISA

Purification

Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:200); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Vallon V., Schroth J, Lang F, Kuhl D and Uchida S. (2009) Am J Physiol Renal Physiol. 297(3): F704-712. 2. Tiwari S., et al. (2009) Am J Nephrol. 30(6): 554-562. 3. Chee K.N., Vorontsova I., Lim J.C., Kistler J. and Donaldson P.J. (2010) Mol Vis. 16:800-812.

Product Datasheet

https://cdn.gentaur.com/products/400/4414103/datasheet/spc-402d-hrp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4414103/msds/spc-402d-hrp.pdf

CAS Number

9007-83-4

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