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NKCC2 Antibody: APC

Rabbit Anti-Rat NKCC2 Polyclonal

Product Specifications

Background

NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell (1, 2). Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide (1).

Specifications

Detects ~160kDa.

Product Name Alternative

Cancer, Neuroscience, Pumps/Transporters, Ion Pumps/Transporters

UNSPSC

12352203

Gene ID

25065

Swiss Prot

Q5PQV1

Accession Number

NP_001257546.1

Cellular Locus

Membrane

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Produced against a synthetic peptide mapping to a segment (amino acids 33-55) of the N-terminal tail of rat NKCC2 (antibody desgination L224).

Target

NKCC2

Clonality

Polyclonal

Conjugation

APC

Validated Applications

IHC,ICC/IF

Purification

Protein A Purified

Concentration

1 mg/ml

Dilution

WB (1:1000); IHC (1:25); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Caceres P.S., Ares G.R., and Ortiz P.A. (2009) J Biol Chem. 284(37): 24965-24971. 2. Xue H., et al. (2009) Neurogastroentrol Motil. 21(10): 1068-1089.

Product Datasheet

https://cdn.gentaur.com/products/400/4414069/datasheet/spc-401d-apc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4414069/msds/spc-401d-apc.pdf

CAS Number

9007-83-4

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