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NHE3 Antibody: HRP

Rabbit Anti-Rat NHE3 Polyclonal

Product Specifications

Background

Sodium-hydrogen exchanger 3 (NHE3; Slc9a3) is an epithelial transport protein that carries out 1:1 exchange of Na+ and H+ across the plasma membrane. It is apically located in the proximal tubule of the kidney, the thick ascending limb of the kidney, and in small intestine (1). NHE3 is phosphorylated and regulated by multiple kinases including PKA, SGK1 and CK2. It can be phosphorylated by calyculin A, and dephosphorylated by PP1 catalytic subunit in vitro (2).

Specifications

Detects ~84kDa.

Product Name Alternative

Cell Signaling, Neuroscience, Pumps/Transporters, Ion Pumps/Transporters, Cancer

UNSPSC

12352203

Gene ID

24784

Swiss Prot

P26433

Accession Number

NP_036786

Cellular Locus

Membrane

Host

Rabbit

Species Reactivity

Rat,Mouse

Immunogen

Synthetic peptide mapping to AA 809 to 831 of rat sequence

Target

NHE3

Clonality

Polyclonal

Conjugation

HRP

Tissue Specificity

Most abundant in colon and small intestine, followed by kidney and stomach. In kidney, expressed in proximal tubules and outer medulla (at protein level)

Validated Applications

WB,IHC,ELISA

Purification

Protein A Purified

Concentration

1 mg/ml

Dilution

WB (1:1000); IHC (1:25); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Kim G.H., Ecelbarger C.A., Knepper M.A. and Packer R.K. (1999) J Am Soc Nephrol. 10: 935-942. 2. Dynia D.W., Steinmetz A.G. and Kocinsky H.S. (2010) Am J Physoil Renal Physiol. 298(3): F745-F753.

Product Datasheet

https://cdn.gentaur.com/products/400/4414053/datasheet/spc-400d-hrp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4414053/msds/spc-400d-hrp.pdf

CAS Number

9007-83-4

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