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Bassoon Antibody: Biotin

Rabbit Anti-Human Bassoon Polyclonal

Product Specifications

Background

Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).

Specifications

Detects ~420kDa. Multiple isoforms can be detected.

Product Name Alternative

Neuroscience, Cell Markers, Neuron Markers, Presynaptic Markers, Neuroscience, Neurodegeneration, Multiple System Atrophy

UNSPSC

12352203

Gene ID

8927

Swiss Prot

Q9UPA5

Accession Number

NP_003449.2

Cellular Locus

Cytoplasm | Cell Junction | Synapse

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein of human Bassoon

Target

Bassoon

Clonality

Polyclonal

Conjugation

Biotin

Validated Applications

WB,IHC,ICC/IF |ELISA

Purification

Protein A Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:400); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

136.36mM Ethanolamine, and 9.55mM Sodium Bicarbonate in 95.45% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Anna Dondzillo et al., (2010) J. Comp Neur, 518(7): 1008–1029.

Product Datasheet

https://cdn.gentaur.com/products/400/4413559/datasheet/spc-198d-bi.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4413559/msds/spc-198d-bi.pdf

CAS Number

9007-83-4

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