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Piccolo Antibody: ATTO 488

Rabbit Anti-Human Piccolo Polyclonal

Product Specifications

Background

Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).

Specifications

Detects ~550kDa. No cross-reactivity to Bassoon.

Product Name Alternative

Neuroscience, Cell Markers, Neuron Markers, Presynaptic Markers

UNSPSC

12352203

Gene ID

27445

Swiss Prot

Q9Y6V0

Accession Number

NP_055325.2

Cellular Locus

Cell Junction | Synapse

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant Full length human Piccolo Protein, BC001304.1

Target

Piccolo

Clonality

Polyclonal

Conjugation

ATTO 488

Validated Applications

IHC,ICC/IF

Purification

Protein A Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:400); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Gerber S.H., Garcia J., Rizo J., Sudhof T.C. (2001) EMBO J. 20(7): 1605-1619. 2. Wang X., et al. (1999) J Cell Biol. 147(1): 151-162. 3. Dresbach T., et al. (2006) J Biol Chem. 281(9):6038-6047.

Product Datasheet

https://cdn.gentaur.com/products/400/4413524/datasheet/spc-197d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4413524/msds/spc-197d-a488.pdf

CAS Number

9007-83-4

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