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HSP110 Antibody: HRP

Rabbit Anti-Hamster HSP110 Polyclonal

Product Specifications

Background

HSP110 belongs to a family of large stress proteins known as the HSP110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied HSP70 family. They share 30-33% amino acid identity, mostly in the conserved ATP-binding domain (1). HSP110 cooperates with HSP70 in protein folding in the eukaryotic cytosol (2). In mammals, HSP110 is constitutively expressed, but exhibits particularly high levels in the brain. Both HSP70 and HSP110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of HSP110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of HSP70 (3). Studies also suggest that HSP110 can be used in heat shock protein-based cancer immunotherapy (4).

Specifications

Detects ~110kDa.

Product Name Alternative

Cancer, Heat Shock, Cell Signaling, Protein Trafficking, Chaperone Proteins

UNSPSC

12352203

Gene ID

10808

Swiss Prot

Q92599

Accession Number

NP_006635.3

Cellular Locus

Cytoplasm

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Bovine,Monkey,Hamster,Sheep,Yeast,Shark

Immunogen

Synthetic peptide derived from the sequence of hamster HSP110; sequence identical to human and mouse

Target

HSP110

Clonality

Polyclonal

Conjugation

HRP

Validated Applications

WB,IHC,ELISA

Purification

Protein A Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Lee-Yoon D., et al. (1995) J Biol Chem. 270: 15725-15733. 2. Dragovic Z., et al. (2006) EMBO J. 25: 2519-2528. 3. Nakamura J., et al. (2008) Stroke. 39(10): 2853-2859. 4. Subject D.R. (2001) Health Research Inc. Report number AS90893: 1-84.

Product Datasheet

https://cdn.gentaur.com/products/400/4413490/datasheet/spc-195d-hrp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4413490/msds/spc-195d-hrp.pdf

CAS Number

9007-83-4

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