Cpn10 Antibody: RPE

Rabbit Anti-Human Cpn10 Polyclonal

Product Specifications

Background

Cpn10 (Chaperonin 10), a member of the HSP10 family, functions as a co-chaperone with HSP60 to facilitate proper protein folding and assembly. It is essential for maintaining proteostasis, particularly under stress conditions such as oxidative damage and inflammation. In the nervous system, Cpn10 supports mitochondrial protein folding and cellular resilience. Its identification as early pregnancy factor and presence in serum suggest systemic regulatory roles, potentially acting as a stress-responsive signaling molecule. Given the central role of protein misfolding in neurodegenerative diseases like Alzheimer’s and Parkinson’s, Cpn10 is a candidate for therapeutic exploration in modulating chaperone networks and preventing proteotoxicity.

CAS Number

9007-83-4

Specifications

Detects ~ 10kDa.

Product Name Alternative

10kDa Chaperonin, Chaperonin 10, Cpn 10, EPF, GROES, Heat Shock 10kD protein1, HSP10, HSPE1

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

3336

Swiss Prot

P61604

Accession Number

NP_002148.1

Cellular Locus

Mitochondrion | Mitochondrion Matrix

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Bovine,Dog,Guinea Pig,Pig,Rabbit,Sheep,Xenopus

Immunogen

Human Cpn10 peptide AA 91-101

Target

Cpn10

Clonality

Polyclonal

Conjugation

RPE

Type

Polyclonal

Applications

WB | IHC | ICC/IF | IP | ELISA

Validated Applications

WB,IHC,ICC/IF

Field of Research

Purification

Protein A Purified

Detection Range

1 µg/ml of SPC-193 was sufficient for detection of Cpn10 in 10 µg of Hela lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Velez-Granell C.S., et al. (1994) J of Cell Science. 107 (3) : 539-549. 2. Morton H., Hegh V., and Clunie G.J.A. (1974) Nature (London) 249: 459-460. 3. Cavanagh A.C., and Morton H. (1994) Eur. J. Biochem. 222: 551-560. 4. Minto M., et al. (1998) Molecular Cell Research. 1403 (2) : 151-157.