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AHA1 Antibody: APC

Rabbit Anti-Mouse AHA1 Polyclonal

Product Specifications

Background

Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).

Specifications

Detects ~ 38kDa.

Product Name Alternative

Cancer, Heat Shock, Cell Signaling, Protein Trafficking, Chaperone Proteins

UNSPSC

12352203

Gene ID

217737

Swiss Prot

Q8BK64

Accession Number

NP_666148.1

Cellular Locus

Cytoplasm | Endoplasmic Reticulum

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant Full Length Mouse Aha1 Protein

Target

AHA1

Clonality

Polyclonal

Conjugation

APC

Validated Applications

IHC,ICC/IF

Purification

Protein A Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:60); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub. 2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796. 3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723. 4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.

Product Datasheet

https://cdn.gentaur.com/products/400/4413301/datasheet/spc-183d-apc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4413301/msds/spc-183d-apc.pdf

CAS Number

9007-83-4

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