P38 Antibody

Rabbit Anti-Human p38 Polyclonal

Product Specifications

Background

P38 is a member of the mitogen-activated protein kinase (MAPK) family, specifically involved in cellular responses to stress and inflammation. In the nervous system, p38 plays a pivotal role in regulating apoptosis, neuroinflammation, and synaptic plasticity—processes that are frequently dysregulated in neurodegenerative diseases. Upon activation by environmental and cellular stressors such as oxidative damage, cytokines, and UV radiation, p38 translocates to the nucleus where it modulates transcription factors and pro-apoptotic proteins. This leads to the release of cytochrome c, activation of caspase-3, and cleavage of PARP, promoting programmed cell death. In Alzheimer’s, Parkinson’s, and ALS, aberrant p38 signaling contributes to neuronal loss, glial activation, and neurodegenerative phenotypes. As a result, p38 has emerged as a therapeutic target for modulating neuroinflammation and preventing neuronal degeneration.

CAS Number

9007-83-4

Specifications

Detects ~43kDa.

Product Name Alternative

CSAID Binding protein 1, CSBP1, CSBP2, EXIP, MAP kinase MXI2, MAPkinase p38alpha, MAPK14, p38 ALPHA, p38 MAP kinase, p38 mitogen activated protein kinase, RK, SAPK 2A, Stress activated protein kinase 2A

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

1432

Swiss Prot

Q16539

Accession Number

NP_001306.1

Cellular Locus

Cytoplasm | Nucleus

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Bovine,Monkey,Rabbit,Pig,Dog,Hamster,Chicken,Sheep,Guinea pig

Immunogen

A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH

Target

p38

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Polyclonal

Applications

WB | IHC | ICC/IF | IP

Validated Applications

WB,IHC,ICC/IF,IP

Field of Research

Cell Signaling | Post-translational Modifications | Phosphorylation | Cancer

Purification

Peptide Affinity Purified

Detection Range

A 1:1000 dilution of SPC-172 was sufficient for detection of p38 in 20 µg of HeLa cell lysate by ECL immunoblot analysis.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100), IP (1:250) ; optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Pearson G., et al (2001) Endocrine Reviews 22 (2) : 153-183. 2. Fan Y., et al (2007) Mol. Cells 23 (1) : 30-38. 3. Han J., et al. (1994) Science 265: 808-811. 4. Van L. A., et al. (2004) Faseb J. 18: 1946−1948. 5. Deng et al. (2003) Cell 115: 61-70. 6. Salojin K.V., et al. (2006) J Immunol. 176 (3) :1899-907. 7. Medicherla S., et al. (2006) J Pharmacol Exp Ther. 318 (1) : 99-107.