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TNF-R1 Antibody: HRP

Rabbit Anti-Mouse TNF-R1 Polyclonal

Product Specifications

Background

The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-α. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-α/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.

Specifications

Detects ~55kDa. Other bands present may be the result of oligomerization, self-aggregation and/or cleavage of the TNF-R1 extracellular domain.

Product Name Alternative

Cancer, Apoptosis, Cell Signaling, Cardiovascular System, Atherosclerosis

UNSPSC

12352203

Gene ID

7132

Swiss Prot

P19438

Cellular Locus

Cell Membrane | Golgi Apparatus | Golgi Apparatus Membrane

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Bovine,Monkey,Dog,Rabbit

Immunogen

Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues

Target

TNFR1

Clonality

Polyclonal

Conjugation

HRP

Validated Applications

WB,IHC,ELISA

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Kontermann R.E., et al. (2008) J Immunother. 31(3):225-34. 2. Hehlgans T. and Pfeffer K. (2005) Immunology. 115(1):1-20. 3. Al-Lamki S., et al. (2005) The Faseb Journal. 19:1638-1645.

Product Datasheet

https://cdn.gentaur.com/products/400/4413077/datasheet/spc-170d-hrp.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4413077/msds/spc-170d-hrp.pdf

CAS Number

9007-83-4

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