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TNF-R1 Antibody: Biotin

Rabbit Anti-Mouse TNF-R1 Polyclonal

Product Specifications

Background

The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-α. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-α/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.

Specifications

Detects ~55kDa. Other bands present may be the result of oligomerization, self-aggregation and/or cleavage of the TNF-R1 extracellular domain.

Product Name Alternative

Cancer, Apoptosis, Cell Signaling, Cardiovascular System, Atherosclerosis

UNSPSC

12352203

Gene ID

7132

Swiss Prot

P19438

Cellular Locus

Cell Membrane | Golgi Apparatus | Golgi Apparatus Membrane

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Bovine,Monkey,Dog,Rabbit

Immunogen

Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues

Target

TNFR1

Clonality

Polyclonal

Conjugation

Biotin

Validated Applications

WB,IHC,ICC/IF |ELISA

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

136.36mM Ethanolamine, and 9.55mM Sodium Bicarbonate in 95.45% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Kontermann R.E., et al. (2008) J Immunother. 31(3):225-34. 2. Hehlgans T. and Pfeffer K. (2005) Immunology. 115(1):1-20. 3. Al-Lamki S., et al. (2005) The Faseb Journal. 19:1638-1645.

Product Datasheet

https://cdn.gentaur.com/products/400/4413070/datasheet/spc-170d-bi.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4413070/msds/spc-170d-bi.pdf

CAS Number

9007-83-4

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