TNF-R1 Antibody: ATTO 594

Tumor necrosis factor receptor 1 (TNF-R1), also known as CD120a or p55/p60, is a high-affinity receptor for tumor necrosis factor-alpha (TNF-α) and a key member of the TNF/TNFR superfamily. Structurally, TNF-R1 features an extracellular domain with multiple cysteine-rich repeats and a cytoplasmic death domain that initiates downstream signaling cascades. TNF-R1 is widely expressed in the central nervous system, including neurons, astrocytes, and microglia. Upon binding TNF-α, TNF-R1 activates multiple intracellular pathways, including NF-κB-mediated inflammation and caspase-dependent apoptosis. This dual functionality allows TNF-R1 to regulate both cell survival and programmed cell death, depending on the cellular context and signaling environment. In neurodegenerative disease research, TNF-R1 has emerged as a critical mediator of chronic neuroinflammation and neuronal loss. Aberrant TNF-R1 signaling is implicated in the pathogenesis of Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) . Sustained activation of TNF-R1 can exacerbate oxidative stress, synaptic dysfunction, and glial reactivity—hallmarks of progressive neurodegeneration. Given its central role in immune signaling and apoptosis, TNF-R1 is a promising therapeutic target for modulating neuroinflammatory responses and protecting neuronal integrity in neurodegenerative disorders.

1 µg/ml of SPC-170 was sufficient for detection of TNFR1 in 20 µg of Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

1. Kontermann R.E., et al. (2008) J Immunother. 31 (3) :225-34. 2. Hehlgans T. and Pfeffer K. (2005) Immunology. 115 (1) :1-20. 3. Al-Lamki S., et al. (2005) The Faseb Journal. 19:1638-1645.