CDC37 Antibody
Rabbit Anti-Human CDC37 Polyclonal
Product Specifications
Background
HSP90 co-chaperone Cdc37 is a protein that is encoded by the CDC37 gene. It has been found to form complexes with HSP90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK and elF-2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases (1, 2). CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multi-targeted therapies (3, 4).
Specifications
Detects ~44.5kDa.
Product Name Alternative
Cancer, Heat Shock, Cell Signaling, Epigenetics and Nuclear Signaling
UNSPSC
12352203
Gene ID
11140
Swiss Prot
Q16543
Accession Number
NP_008996.1
Cellular Locus
Cytoplasm
Host
Rabbit
Species Reactivity
Human
Immunogen
Native human Cdc37, full length
Target
CDC37
Clonality
Polyclonal
Conjugation
Unconjugated
Validated Applications
WB,ICC/IF
Purification
Protein A Purified
Concentration
1.68 mg/ml
Dilution
WB (1:2000), ICC/IF (1:200); optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Dai K, Kobayashi R., Beach D. (1996) J Biol Chem. 271(36): 22030-22034.
2. Stepanova L, Leng X., Parker S.B., Harper J.W. (1996) Genes Dev. 10(12): 1491-1502.
3. Kimura Y., et al. (1997) Genes Dev. 11(14): 1775-1185.
4. Gray P.J., et al. (2008) Nat Rev Cancer. 8(7): 491-495.
Product MSDS
https://cdn.gentaur.com/products/400/4412686/msds/spc-142s.pdf
CAS Number
9007-83-4
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