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CDC37 Antibody: ATTO 488

Rabbit Anti-Human CDC37 Polyclonal

Product Specifications

Background

HSP90 co-chaperone Cdc37 is a protein that is encoded by the CDC37 gene. It has been found to form complexes with HSP90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK and elF-2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases (1, 2). CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multi-targeted therapies (3, 4).

Specifications

Detects ~44.5kDa.

Product Name Alternative

Cancer, Heat Shock, Cell Signaling, Epigenetics and Nuclear Signaling

UNSPSC

12352203

Gene ID

11140

Swiss Prot

Q16543

Accession Number

NP_008996.1

Cellular Locus

Cytoplasm

Host

Rabbit

Species Reactivity

Human

Immunogen

Native human Cdc37, full length

Target

CDC37

Clonality

Polyclonal

Conjugation

ATTO 488

Validated Applications

IHC,ICC/IF

Purification

Protein A Purified

Concentration

1.68 mg/ml

Dilution

WB (1:2000), ICC/IF (1:200); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Dai K, Kobayashi R., Beach D. (1996) J Biol Chem. 271(36): 22030-22034. 2. Stepanova L, Leng X., Parker S.B., Harper J.W. (1996) Genes Dev. 10(12): 1491-1502. 3. Kimura Y., et al. (1997) Genes Dev. 11(14): 1775-1185. 4. Gray P.J., et al. (2008) Nat Rev Cancer. 8(7): 491-495.

Product Datasheet

https://cdn.gentaur.com/products/400/4412664/datasheet/spc-142d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4412664/msds/spc-142d-a488.pdf

CAS Number

9007-83-4

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