Erk1/2 Antibody

Rabbit Anti-Rat Erk1/2 Polyclonal

Product Specifications

Background

Extracellular signal-regulated kinases 1 and 2 (Erk1/2) are central components of the MAPK signaling cascade, orchestrating cellular responses to growth factors, stress, and synaptic activity. In the nervous system, Erk1/2 regulate neuronal differentiation, synaptic plasticity, and memory formation. Dysregulation of Erk1/2 signaling has been implicated in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease. Aberrant Erk1/2 activation can lead to chronic neuroinflammation, oxidative stress, and tau hyperphosphorylation—hallmarks of neurodegeneration. Conversely, controlled Erk1/2 signaling supports neuroprotection, axonal regeneration, and cognitive resilience. This dual role positions Erk1/2 as both a biomarker and a therapeutic target in neurodegenerative research. As precision medicine advances, modulating Erk1/2 activity offers a promising strategy to restore neuronal function and delay disease progression.

CAS Number

9007-83-4

Specifications

Detects ~44kda (ERK1) and ~42kDa (ERK2).

Product Name Alternative

ERK1, ERK2, ERT1, ERT2, MAP kinase 1, MAP kinase 2, MAPK1, MAPK2, MAPK3, p38, p40, p41, p41mapk, p42 MAPK, p44 ERK1, p44 MAPK, PRKM1, PRKM2, PRKM3

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

50689

Swiss Prot

P21708

Accession Number

NP_059043.1

Cellular Locus

Cytoplasm | Nucleus

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Bovine,Sheep,Chicken,Drosophila,Xenopus

Immunogen

A 35 residue synthetic peptide, corresponding to Rat Erk1 MAP kinase with the CGG spacer group added and the peptide coupled to KLH.

Target

ERK1

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Polyclonal

Applications

WB | IHC | ICC/IF | FCM

Validated Applications

WB,IHC,ICC/IF,FCM

Field of Research

Purification

Peptide Affinity Purified

Detection Range

A 1:1000 dilution of SPC-120 was sufficient for detection of ERK1/2 in 20 µg of HeLa cell lysate by ECL immunoblot analysis.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:100), ICC/IF (1:100), FCM (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Boulton TG. et al. (1991) Biochemistry. 30 (1) :278-86. 2. Yoon S., and Seger R. (2006) Growth Factors 24:21-44. 3. Wolf G. (2005) Antioxid Redox Signal 7:1337-1345. 4. Chuerland D., Marmor G., Shainskaya A. and Seger R. (2008) J Biol Chem. Epub: http://www.jbc.org/cgi/doi/10.1074/jbc.M709030200 5. Zhuang S., and Schnellmann R.G. (2006) J Pharmacol Exp Ther 319:991-997.