What is the catalog number for PDI Antibody: FITC?

The catalog number for PDI Antibody: FITC is SPC-114D-FITC.

What sizes are available for PDI Antibody: FITC?

PDI Antibody: FITC is available in the following size(s): 100 µL.

Is PDI Antibody: FITC in stock?

PDI Antibody: FITC is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for PDI Antibody: FITC?

The safety data sheet for PDI Antibody: FITC is available here: https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf.

PDI Antibody: FITC

Rabbit Anti-Rat PDI Polyclonal

Product Specifications

Background

Protein disulfide isomerase (PDI) is a thiol-disulfide oxidoreductase that facilitates protein folding and quality control in the endoplasmic reticulum (ER) . In neurons, PDI plays a protective role by preventing the accumulation of misfolded proteins and maintaining redox homeostasis. Under conditions of ER stress—common in neurodegenerative diseases—PDI expression is upregulated as part of the unfolded protein response (UPR) . However, excessive or dysfunctional PDI activity has been linked to protein aggregation and oxidative damage in Alzheimer’s, ALS, and Parkinson’s disease. PDI’s dual role in neuroprotection and pathology makes it a compelling target for therapeutic strategies aimed at modulating ER stress and proteostasis in neurodegeneration.

CAS Number

9007-83-4

Specifications

Detects ~58kDa.

Product Name Alternative

Thioredoxin domain containing 5, ERP46, UNQ364, MGC3178, FLJ21353, FLJ90810, thioredoxin related protein, endothelial protein disulphide isomeras

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Swiss Prot

P04785

Cellular Locus

Endoplasmic Reticulum | Endoplasmic Reticulum Lumen

Host

Rabbit

Species Reactivity

Human,Mouse,Rat,Bovine,Dog,Hamster,Guinea Pig,Sheep,Pig,Xenopus,Mollusk

Immunogen

AA499-509 of Rat PDI

Target

PDI

Clonality

Polyclonal

Conjugation

FITC

Type

Polyclonal

Applications

WB | IHC | ICC/IF | IP

Validated Applications

IHC,ICC/IF

Field of Research

Cell Signaling | Protein Trafficking | Chaperone Proteins | Tags and Cell Markers | Organelle Markers

Purification

Protein A purified

Detection Range

A 1:1000 dilution of SPC-114 was sufficient for detection of PDI in 20 µg of HeLa cell lysate by ECL immunoblot analysis.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. NA K.S. et al. (2007) Mol Cells. 24 (2) : 261-7. 2. Mayer M., Kies U., Kammermeier R., and Buchner J. (2000) J Biol Chem. 275 (38) : 29421-5. 3. Delom F., Mallet B., Carayon P., and Lejeune P.J. (2001) J Biol Chem 276 (24) : 21337-42. 4. Schultz-Norton J.R., McDonald W.H., Yates J.R. and Nardulli A.M. (2006) Mol Endocrinol 20 (9) : 1982-95. 5. Turano C., Coppari S. Altieri F. and Ferraro (2002) J Cell Physiol 193: 154-163. 6. Janiszewski M. (2005) J. Biol Chem. 280 (49) : 40813- 40819. 7. Yoshimori T., et al. (1990) J Biol Chem. 265 (26) : 15984-90.