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KDEL Antibody

Rabbit Anti-KDEL Polyclonal

Product Specifications

Background

The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). Grp78 and Grp94 and PDI all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER.

Specifications

Detects KDEL proteins, GRP94, Grp78, PDI and calreticulin. It may also see ERp57 and ERp29.

Product Name Alternative

Cell Signaling, Tags and Cell Markers, Organelle Markers, Protein Trafficking, Chaperone Proteins

UNSPSC

12352203

Cellular Locus

Endoplasmic Reticulum

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

KDEL containing peptide immunogen

Target

KDEL

Clonality

Polyclonal

Conjugation

Unconjugated

Validated Applications

WB,ICC/IF,IHC

Purification

Protein A Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Ozawa K., et al. (2008) Mol Pharmacol. 74:1610. 2. Austin R.C., et al. (2003) J Biol Chem. 278: 17438.

Product MSDS

https://cdn.gentaur.com/products/400/4412299/msds/spc-109s.pdf

CAS Number

9007-83-4

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