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σ1 Receptor ligand 1

σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki of 3.9 nM. σ1 Receptor ligand 1 has a high plasma protein binding (89%) and promising metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 can be utilized in neurological and cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/σ1-receptor-ligand-1.html

Smiles

COC1=CC=C(C=C1)C2CCOC3(C2)CCN(CC3)CC4=CN=CC=C4

Molecular Formula

C22H28N2O2

Molecular Weight

352.47

References & Citations

[1]Tobias W, et al. Synthesis and structure-affinity relationships of spirocyclic σ1 receptor ligands with tetrahydropyran scaffold, European Journal of Medicinal Chemistry, October 2024

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Sigma 1 Receptor

Frequently Asked Questions

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