σ1 Receptor ligand 1
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki of 3.9 nM. σ1 Receptor ligand 1 has a high plasma protein binding (89%) and promising metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 can be utilized in neurological and cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/σ1-receptor-ligand-1.html
Smiles
COC1=CC=C(C=C1)C2CCOC3(C2)CCN(CC3)CC4=CN=CC=C4
Molecular Formula
C22H28N2O2
Molecular Weight
352.47
References & Citations
[1]Tobias W, et al. Synthesis and structure-affinity relationships of spirocyclic σ1 receptor ligands with tetrahydropyran scaffold, European Journal of Medicinal Chemistry, October 2024
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor
Frequently Asked Questions
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