Galanthamine-d6

Galanthamine-d6 (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].

Product Specifications

CAS Number

[1128109-00-1]

UNSPSC

12352005

Target

Apoptosis; Cholinesterase (ChE)

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O(C([2H])([2H])[2H])C1=C2C=3[C@]4([C@@](O2)(C[C@@H](O)C=C4)[H])CCN(C([2H])([2H])[2H])CC3C=C1

Molecular Formula

C17H15D6NO3

Molecular Weight

293.39

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3 (SI 1) :67-86.|[3]Kuryatov A, et al. Roles of accessory subunits in alpha4beta2 (*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74 (1) :132-43.|[4]Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl) . 2013 Feb;225 (3) :543-51.