Galanthamine-d6
Galanthamine-d6 (Galantamine-d6) is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM[1][2].
Product Specifications
CAS Number
[1128109-00-1]
UNSPSC
12352005
Target
Apoptosis; Cholinesterase (ChE)
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O(C([2H])([2H])[2H])C1=C2C=3[C@]4([C@@](O2)(C[C@@H](O)C=C4)[H])CCN(C([2H])([2H])[2H])CC3C=C1
Molecular Formula
C17H15D6NO3
Molecular Weight
293.39
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3 (SI 1) :67-86.|[3]Kuryatov A, et al. Roles of accessory subunits in alpha4beta2 (*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74 (1) :132-43.|[4]Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl) . 2013 Feb;225 (3) :543-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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