PROTAC SMARCA2 degrader-10
PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 90 after 24 h of treatment[1].
Product Specifications
CAS Number
2568279-34-3
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-10.html
Smiles
O=C(C1=CC=C(C2=CC=C(C=C2)CN3CCC(CC3)CN4C=C(C5=C(N)N=NC(C6=C(C=CC=C6)O)=C5)C=N4)C=C1)N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O
Molecular Formula
C55H60N10O5S
Molecular Weight
973.19
References & Citations
[1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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