Perindopril (erbumine)

Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure[1][2][3][4].

Product Specifications

CAS Number

[107133-36-8]

Product Name Alternative

Perindopril (tert-butylamine salt) ; S-9490 (erbumine)

UNSPSC

12352005

Hazard Statement

H302, H361

Target

Angiotensin-converting Enzyme (ACE) ; NF-κB; Sirtuin; STAT

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Perindopril-erbumine.html

Purity

99.98

Solubility

DMSO : 10 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

O=C([C@H]1N(C([C@@H](N[C@H](C(OCC)=O)CCC)C)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O.CC(C)(C)N

Molecular Formula

C23H43N3O5

Molecular Weight

441.60

Precautions

H302, H361

References & Citations

[1]Bhat S A, et al. Angiotensin receptor blockade modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation better than angiotensin-converting enzyme inhibition [J]. Molecular neurobiology, 2016, 53: 6950-6967.|[2]Wei X, et al. Combination of perindopril erbumine and huangqi-danshen decoction protects against chronic kidney disease via sirtuin3/mitochondrial dynamics pathway [J]. Evidence-Based Complementary and Alternative Medicine, 2022, 2022.|[3]Afonso T, et al. Pharmacodynamic evaluation of 4 angiotensin‐converting enzyme inhibitors in healthy adult horses [J]. Journal of veterinary internal medicine, 2013, 27 (5) : 1185-1192.|[4]Thybo N K, et al. Dose-dependent effects of perindopril on blood pressure and small-artery structure [J]. Hypertension, 1994, 23 (5) : 659-666.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

SIRT3; STAT3

Citation 01

Biosci Rep. 2021 Oct 29;41 (10) :BSR20211598.|Br J Pharmacol. 2021 Mar;178 (5) :1164-1181.|Evid Based Complement Alternat Med. 2022 May 21;2022:5812105.|Stem Cell Res Ther. 2024 Oct 23;15 (1) :375.|Biomed Pharmacother. 2023 Apr:160:114370.|Phytomedicine. 2024 Oct 28:135:156187.