Tubulin inhibitor 6

Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1].

Product Specifications

CAS Number

[105925-39-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-inhibitor-6.html

Purity

98.97

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(N1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13)C4=CC=C(OC)C=C4

Molecular Formula

C20H14ClNO2S

Molecular Weight

367.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54 (12) :4247-63.