(±) -2-Propyl-4-pentenoic acid
(±) -2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±) -2-Propyl-4-pentenoic acid exhibits neuroteratogenicity[1][2].
Product Specifications
CAS Number
[1575-72-0]
Product Name Alternative
4-en-VPA; 2-Allylpentanoic acid
UNSPSC
12352211
Hazard Statement
H290, H314
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/racemic-2-propyl-4-pentenoic-acid.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CCC(CCC)C(O)=O
Molecular Formula
C8H14O2
Molecular Weight
142.20
Precautions
H290, H314
References & Citations
[1]W Tang, et, al. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics. Drug Metab Dispos. 1997 Feb;25 (2) :219-27.|[2]Gofflot F, et, al. In vitro neuroteratogenicity of valproic acid and 4-en-VPA. Neurotoxicol Teratol. Jul-Aug 1995;17 (4) :425-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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