(±) -2-Propyl-4-pentenoic acid

(±) -2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±) -2-Propyl-4-pentenoic acid exhibits neuroteratogenicity[1][2].

Product Specifications

CAS Number

[1575-72-0]

Product Name Alternative

4-en-VPA; 2-Allylpentanoic acid

UNSPSC

12352211

Hazard Statement

H290, H314

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/racemic-2-propyl-4-pentenoic-acid.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=CCC(CCC)C(O)=O

Molecular Formula

C8H14O2

Molecular Weight

142.20

Precautions

H290, H314

References & Citations

[1]W Tang, et, al. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics. Drug Metab Dispos. 1997 Feb;25 (2) :219-27.|[2]Gofflot F, et, al. In vitro neuroteratogenicity of valproic acid and 4-en-VPA. Neurotoxicol Teratol. Jul-Aug 1995;17 (4) :425-35.