JAK-IN-38
JAK-IN-38 (Compound 1) is a JAK inhibitor, with IC50s of 0.03, 0.06, 0.12, 0.44 μM for Tyk2, JAK3, JAK2, JAK1 respectively. JAK-IN-38 is a collagen VII (C7) inducer and has anti-inflammatory activity. JAK-IN-38 can upregulate the expression of COL7A1 mRNA in donor-derived keratinocytes and works together with Gentamicin to boost overall C7 levels[1].
Product Specifications
UNSPSC
12352211
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/adenosine-receptor-modulator-1.html
Smiles
[H][C@@]1(C2CC3CC1C[C@@](C3)(C2)O)NC(C4=C(N=CC(C5=CC=C6C=CN(C6=C5)CC(N)=O)=N4)N)=O
Molecular Formula
C25H28N6O3
Molecular Weight
460.53
References & Citations
[1]Jover I, et al. Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosa. Sci Rep. 2024 Aug 16;14 (1) :18969.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; JAK2; JAK3; Tyk2
Frequently Asked Questions
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