(E/Z) -Elafibranor
(E/Z) -Elafibranor ((E/Z) -GFT505) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively[1][2][3].
Product Specifications
CAS Number
824932-88-9
Product Name Alternative
(E/Z) -GFT505
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/e-z-elafibranor.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C)(C)OC1=C(C)C=C(/C=C/C(C2=CC=C(C=C2)SC)=O)C=C1C)O
Molecular Formula
C22H24O4S
Molecular Weight
384.49
References & Citations
[1]Liu ZM, et al. Early investigational drugs targeting PPAR-α for the treatment of metabolic disease.Expert Opin Investig Drugs. 2015 May;24 (5) :611-21.|[2]Ratziu V, et al. Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening. Gastroenterology. 2016 May;150 (5) :1147-1159.|[3]Hanf R, et al. The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.Diab Vasc Dis Res. 2014 No
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNUB0958-100 1x 100 µL
Double Stranded DNA (dsDNA) (DSD/958), 0.2mg/mL
Sign In for Pricing
View Details 