(E/Z) -Elafibranor
(E/Z) -Elafibranor ((E/Z) -GFT505) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively[1][2][3].
Product Specifications
CAS Number
824932-88-9
Product Name Alternative
(E/Z) -GFT505
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/e-z-elafibranor.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C)(C)OC1=C(C)C=C(/C=C/C(C2=CC=C(C=C2)SC)=O)C=C1C)O
Molecular Formula
C22H24O4S
Molecular Weight
384.49
References & Citations
[1]Liu ZM, et al. Early investigational drugs targeting PPAR-α for the treatment of metabolic disease.Expert Opin Investig Drugs. 2015 May;24 (5) :611-21.|[2]Ratziu V, et al. Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening. Gastroenterology. 2016 May;150 (5) :1147-1159.|[3]Hanf R, et al. The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.Diab Vasc Dis Res. 2014 No
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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