NPP3-IN-1
NPP3-IN-1 (Compound 3e) is an inhibitor of phosphodiesterase/pyrophosphatase-3 (NPP3) (IC50: 0.24 μM and 1.37 μM for NPP3 and NPP1 respectively[1].
Product Specifications
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/npp3-in-1.html
Solubility
10 mM in DMSO
Smiles
S=C(N/N=C/C1=CC=C(N2CCOCC2)C=C1)NC3=CC=CC([N+]([O-])=O)=C3
Molecular Formula
C18H19N5O3S
Molecular Weight
385.44
References & Citations
[1]Tasleem M, et al. Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors. Int J Biol Macromol. 2024 May;266 (Pt 2) :131068.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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