K02288

K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM.

Product Specifications

CAS Number

[1431985-92-0]

UNSPSC

12352005

Hazard Statement

H301, H318

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/K02288.html

Concentration

10mM

Purity

99.65

Solubility

DMSO : ≥ 58.6 mg/mL

Smiles

OC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1

Molecular Formula

C20H20N2O4

Molecular Weight

352.38

Precautions

H301, H318

References & Citations

[1]Sanvitale CE, et al. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8 (4) :e62721.|[2]Kerr G, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis. 2015 Apr;18 (2) :209-17.