Guvacine hydrochloride

Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3) .

Product Specifications

CAS Number

[6027-91-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Guvacine_hydrochloride.html

Purity

99.93

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 41.67 mg/mL (ultrasonic)

Smiles

O=C(C1=CCCNC1)O.[H]Cl

Molecular Formula

C6H10ClNO2

Molecular Weight

163.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Borden LA, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269 (2) :219-24.|[2]Krogsgaard-Larsen P, et al. Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J Neurochem. 1978 Jun;30 (6) :1377-82.|[3]Lodge D, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136 (3) :513-22.