Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Vasculotide (TFA)

Vasculotide TFA, an angiopoietin-1 mimetic, is a Tie-2 activator and induces Tie-2 phosphorylation. Vasculotide has anti-inflammatiory effect and anti-permeability. Vasculotide TFA ameliorates endotoxin-induced endothelial barrier dysfunction. Vasculotide TFA promotes angiogenesis in a mouse model of diabetic ulcer. Vasculotide TFA protects mice from vascular leakage and reduces mortality in murine abdominal sepsis. Vasculotide TFA decreases microvascular leakage and improves microcirculatory perfusion in a rat model of hemorrhagic shock[1][2][3].

Product Specifications

UNSPSC

12352209

Target

Tie

Type

Peptides

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vasculotide-tfa.html

Purity

99.72

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(CCN1C(CC(SC[C@@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](CC3=CN=CN3)C(N[C@@H](CC4=CN=CN4)C(N[C@H](CCCNC(N)=N)C(N[C@@H](CC5=CN=CN5)C(N[C@H](CO)C(N[C@H](C(O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O)=O)N)C1=O)=O)NCCOCCOCC(COCCOCCNC(CCN7C(C(SC[C@@H](C(N[C@@H](CC8=CN=CN8)C(N[C@H](CC9=CN=CN9)C(N[C@@H](CC%10=CN=CN%10)C(N[C@H](CCCNC(N)=N)C(N[C@@H](CC%11=CN=CN%11)C(N[C@H](CO)C(N[C@H](C(O)=O)CC%12=CC=CC=C%12)=O)=O)=O)=O)=O)=O)=O)N)CC7=O)=O)=O)(COCCOCCNC(CCN%13C(C(SC[C@H](N)C(N[C@@H](CC%14=CN=CN%14)C(N[C@H](CC%15=CN=CN%15)C(N[C@@H](CC%16=CN=CN%16)C(N[C@H](CCCNC(N)=N)C(N[C@@H](CC%17=CN=CN%17)C(N[C@H](CO)C(N[C@H](C(O)=O)CC%18=CC=CC=C%18)=O)=O)=O)=O)=O)=O)=O)CC%13=O)=O)=O)COCCOCCNC(CCN%19C(C(SC[C@H](N)C(N[C@@H](CC%20=CN=CN%20)C(N[C@H](CC%21=CN=CN%21)C(N[C@@H](CC%22=CN=CN%22)C(N[C@H](CCCNC(N)=N)C(N[C@@H](CC%23=CN=CN%23)C(N[C@H](CO)C(N[C@H](C(O)=O)CC%24=CC=CC=C%24)=O)=O)=O)=O)=O)=O)=O)CC%19=O)=O)=O.O=C(O)C(F)(F)F.[n].[n].[n].[n].[x]

Molecular Weight

14000 (average)

References & Citations

[1]David S, et al. Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol. 2011 Jun;300 (6) :L851-62.|[2]Kumpers P, et al. The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care. 2011;15 (5) :R261.|[3]Trieu M, et al. Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock. Anesthesiology. 2018 Feb;128 (2) :361-374.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

NXF1 Antibody, mAb, Rabbit
A04882-50 50 µL

NXF1 Antibody, mAb, Rabbit

Sign In for Pricing
View Details
4- (2,5-Dimethyl-pyrrol-1-yl) -benzoic acid
428727-01 100 mg

4- (2,5-Dimethyl-pyrrol-1-yl) -benzoic acid

Sign In for Pricing
View Details
4- (2,5-Dimethyl-pyrrol-1-yl) -benzoic acid
428727-02 250 mg

4- (2,5-Dimethyl-pyrrol-1-yl) -benzoic acid

Sign In for Pricing
View Details
Dynein, axonemal, intermediate chain 2
314153 100 µL

Dynein, axonemal, intermediate chain 2

Sign In for Pricing
View Details
PPAN CRISPR All-in-one AAV vector set (with saCas9)(Human)
37287151 3x 1.0 µg DNA

PPAN CRISPR All-in-one AAV vector set (with saCas9)(Human)

Sign In for Pricing
View Details
PGL3 Antibody
orb793402 2 mg

PGL3 Antibody

Sign In for Pricing
View Details